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Cyld spata2

WebDec 2, 2024 · IntroductionColorectal cancer (CRC) is largely refractory to currently available immunotherapies such as blockade of programmed cell death protein-1 (PD-1).ResultsIn this study, we identified SPATA2 and its protein partner CYLD as novel regulators of CXC-ligand 10 (CXCL10), a T-cell-attractant chemokine, in CRC. By specifically deleting SPATA2 … WebAug 17, 2016 · Specifically, the ability of SPATA2 to interact with CYLD promotes the assembly of a complex consisting of a hetero-tetramer which then interacts with two LUBAC complexes by means of HOIP [9,10,12].

PLK4 deubiquitination by Spata2‐CYLD suppresses NEK7

WebOct 5, 2024 · CYLD is a comparably well-studied DUB in terms of its activity, specificity, and regulation. It is an unusual and divergent member of the Ub-specific protease (USP) family of DUBs, since its structurally distinct USP domain preferentially hydrolyses Met1- and Lys63-Ub ( Komander et al., 2008, 2009; Sato et al., 2015 ). WebJun 17, 2024 · The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and regulates Met1- and Lys63-linked polyubiquitin and receptor signaling outcomes ... Macromolecules Find similar proteins by: (by identity cutoff) 3D Structure Find similar proteins by: (by identity cutoff) 3D Structure family control test https://xlaconcept.com

The SPATA2/CYLD pathway contributes to doxorubicin-induced ...

WebJun 17, 2024 · The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and regulates Met1- and Lys63-linked polyubiquitin and receptor signaling outcomes. Here, we investigate the molecular determinants of CYLD activity. We reveal that two CAP-Gly domains in CYLD are … WebDec 1, 2024 · There are reports that spermatogenesis-associated protein 2 (SPATA2) acts as an allosteric activator for CYLD. SPATA2 interacts via its PUB domain with CYLD, which activates the deubiquitinase activity of CYLD [18]. Thus, it is likely that the SPATA2/CYLD pathway plays an important role in regulation of doxorubicin-induced ferritinophagy. WebThe CYLD protein exerts its neuroprotective effects via interaction with SPATA2. SPATA2 recruits CYLD to LUBAC to deconjugate K63-linked polyubiquitin chains. The LUBAC complex is composed of longer isoforms of heme-oxidized iron-regulatory protein 2 ubiquitin ligase-1 (HOIL-1), HOIL-1 interacting protein ... cooker snicker pie

SPATA2 Links CYLD to LUBAC, Activates CYLD, and …

Category:The SPATA2/CYLD pathway contributes to doxorubicin …

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Cyld spata2

Spata2 Knockdown Exacerbates Brain Inflammation via NF …

WebIn cells, SPATA2 is recruited to the TNF receptor 1 signaling complex and is required for CYLD recruitment. Loss of SPATA2 increases ubiquitination … WebSep 15, 2016 · We here show that CYLD interacts with HOIP via spermatogenesis-associated protein 2 (SPATA2). SPATA2 interacts with CYLD through its non-canonical …

Cyld spata2

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http://genesdev.cshlp.org/content/early/2024/07/12/gad.299776.117.full.pdf Webmatogenesis-Associated Protein 2 (SPATA2) is thought to regulate spermatogenesis in testes [ 26–28]. Recent research has established that SPATA2 is an important partner protein of CYLD [22, 29–31]. Specically, SPATA2 functions as an adaptor that recruits CYLD to signaling complexes and allosterically activates CYLD. However, unlike CYLD, the

WebJun 15, 2016 · SPATA2 is a component of the TNF receptor complex and is required to recruit the deubiquitylase CYLD and trigger TNF-α-induced necroptosis. Proteomic … WebRequired to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity). Uniprot Accession IDs. Q9UM82 open_in_new.

WebAll four reports mapped the CYLD–SPATA2 interac-tion to the C-terminal ubiquitin-specific protease (USP) domain of CYLD and the N-terminus of SPATA2, which contains a PUB domain. Gyrd-Hansen and ...

WebNational Center for Biotechnology Information cooker socket screwfixWebwith CYLD [16,31]. As SPATA2 interacts with CYLD, we postulated that SPATA2 is the bridging factor between CYLD and HOIP. We therefore tested whether SPATA2 interacts with HOIP. Indeed, we found that FLAG-HOIP co-immunoprecipitated with SPATA2 (Fig 2A). As shown previously for CYLD, the interaction of SPATA2 and HOIP also depended … family control windows 10WebJun 17, 2024 · The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and regulates Met1- and Lys63 … cookers northampton