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Kashin beck disease gwas

Webb11 okt. 2016 · Recent study observed defective autophagy in chondrocytes with Kashin–Beck Disease (KBD). To clarify the potential role of autophagy-related ATG4C gene in the development of KBD, we conducted an integrative analysis of genetic association, messenger ribonucleic acid (mRNA) and protein expression of ATG4C in …

Brief Report: Genome-Wide Association Study Identifies

Webb1 nov. 2011 · To evaluate the performance of SWGDT, a real GWAS dataset of Kashin-Beck disease (KBD) was analyzed. Immunohistochemisty was also performed to validate the relevance of identified gene with KBD. Webb13 okt. 2015 · Kashin-Beck disease (KBD) is a chronic osteochondropathy [1, 2], which is prevalent at some areas of China, Russia, and North Korea. KBD is a complex … erb\u0027s point heart sound https://xlaconcept.com

A bivariate genome-wide association study identifies ADAM12 as …

WebbSelenium deficiency causes Keshan disease (cardiomyopathy) and Kashin-Beck disease (osteoarthritis) and has been linked to oxidative stress, inflammation, ... we conducted a two-stage genome-wide association study (GWAS) by using the data from two cohorts to examine the effects of genetic variation on serum selenium concentrations. 2. Subjects ... WebbKashin-Beck disease (KBD) is a chronic osteo- chondropathy, which is mainly characterized by cartilage degeneration, cartilage matrix degradation, chondrocyte necrosis, and apoptosis. KBD usually involves children ages3–12years,andthepatientsexperienceseriousjoint pain, joint deformities, and … Webb1 jan. 2015 · Kashin-Beck disease (KBD) is a chronic osteochondropathy, ... Results The GWAS identified significant association (P = 1.58 × 10(-8) ) between KBD and a novel locus, ITPR2 SNP rs10842750. The replication study showed significant associations with KBD at 9 ITPR2 SNPs, including rs10842750 ... find luggage type for victornix

Genetic variants in the ITPR2 gene are associated with Kashin‐Beck ...

Category:Genome-Wide Association Study Identifies ITPR2 as a …

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Kashin beck disease gwas

Brief Report: Genome-Wide Association Study Identifies

Webb15 jan. 2016 · Objectives: To identify the differences and similarities of differentially expressed genes in peripheral blood mononuclear cells (PBMCs) between Kashin–Beck disease (KBD) grades I and II.Method: In total, 100 patients with KBD and 100 healthy controls were selected from a KBD endemic area and divided into 100 pairs of KBD vs. … WebbThis study aims to uncover insight into the epigenetic modifications for Kashin-Beck disease (KBD) by integrating genome-wide association studies (GWAS), …

Kashin beck disease gwas

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Kashin–Beck disease (KBD) is a chronic, endemic type of osteochondropathy (disease of the bone) that is mainly distributed from northeastern to southwestern China, including 15 provinces. As of 2011, Tibet has the highest incidence rate of KBD in China. Southeast Siberia and North Korea are other affected areas. KBD usually involves children ages 5–15. To date, more than a million individuals have had KBD. The symptoms of KBD include joint pain, morning stiffness in the join… Webb22 aug. 2016 · Kashin-Beck disease (KBD) is a chronic osteoarthropathy, which manifests as joint deformities and growth retardation. Only a few genetic studies of growth retardation associated with the KBD...

Webb6 apr. 2024 · The mission of the Public Health Genomics is to integrate advances in human genetics into public health research, policy, and programs WebbAnother independent sample of 1717 subjects was genotyped for a genome-wide association study (GWAS) using Affymetrix Human SNP 6.0 Arrays. Single …

Webb23 apr. 2016 · Kashin-Beck disease (KBD) is an endemic osteochondropathy (Stone 2009 ), characterized by cartilage degeneration, cartilage matrix degradation, … WebbDuring the past several decades, etiological and geochemical studies tend to link the Kaschin-Beck Disease (KBD) to the deficiency of some specific trace elements (e.g., selenium and iodine) in the environment; however the link has been proven inconclusive. In this work, we have investigated the rel …

WebbKashin-Beck Disease (KBD) is a type of endemic, chronic, and disabling osteoarthropathy with high disability. KBD is also …

Webb× Close. The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. erb\u0027s point spinal accessory nerveWebb1 maj 2024 · Kashin-Beck Disease (KBD) is a type of endemic, chronic, and disabling osteoarthropathy with high disability. ... (GWAS) at a genome-wide significance level, the comprehensive and positive genes were obtained from the supplementary data of … find luggage by record locator deltaWebbKashin beck’s disease Introduction Kashin-Beck disease (KBD) is an endemic chronic osteo-chondropathy, which is prevalent at the Eastern Siberia of Russia, North Korea, … find luis hage evening meditation