Webb11 okt. 2016 · Recent study observed defective autophagy in chondrocytes with Kashin–Beck Disease (KBD). To clarify the potential role of autophagy-related ATG4C gene in the development of KBD, we conducted an integrative analysis of genetic association, messenger ribonucleic acid (mRNA) and protein expression of ATG4C in …
Brief Report: Genome-Wide Association Study Identifies
Webb1 nov. 2011 · To evaluate the performance of SWGDT, a real GWAS dataset of Kashin-Beck disease (KBD) was analyzed. Immunohistochemisty was also performed to validate the relevance of identified gene with KBD. Webb13 okt. 2015 · Kashin-Beck disease (KBD) is a chronic osteochondropathy [1, 2], which is prevalent at some areas of China, Russia, and North Korea. KBD is a complex … erb\u0027s point heart sound
A bivariate genome-wide association study identifies ADAM12 as …
WebbSelenium deficiency causes Keshan disease (cardiomyopathy) and Kashin-Beck disease (osteoarthritis) and has been linked to oxidative stress, inflammation, ... we conducted a two-stage genome-wide association study (GWAS) by using the data from two cohorts to examine the effects of genetic variation on serum selenium concentrations. 2. Subjects ... WebbKashin-Beck disease (KBD) is a chronic osteo- chondropathy, which is mainly characterized by cartilage degeneration, cartilage matrix degradation, chondrocyte necrosis, and apoptosis. KBD usually involves children ages3–12years,andthepatientsexperienceseriousjoint pain, joint deformities, and … Webb1 jan. 2015 · Kashin-Beck disease (KBD) is a chronic osteochondropathy, ... Results The GWAS identified significant association (P = 1.58 × 10(-8) ) between KBD and a novel locus, ITPR2 SNP rs10842750. The replication study showed significant associations with KBD at 9 ITPR2 SNPs, including rs10842750 ... find luggage type for victornix