Post-translational control of nur77

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August undefined, 2024

WebNur77 is a master regulator for Ly6C-monocytes and modulates the inflammatory effect of monocytes and macrophages [ 13, 14 ]. Apoptosis mediated by Nur77 affects thymocyte selection and mature T-cell differentiation. Nur77 also has an effect on T cell tolerance and exhaustion [ 15, 16, 17, 18, 19 ]. WebNur77 translocation is induced by certain apoptotic stimuli, including the synthetic retinoid-related 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN)/CD437 …

Transcriptional regulation of autophagy and its implications in …

Web7 Dec 2006 · Nur77 (also known as TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, controls both survival and death of cancer cells. A wealth of recent … Web1 Dec 2006 · Nur77 is a nuclear orphan receptor that has been implicated in both cell survival and apoptosis. With the exception of T-cells, translocation of Nur77 to the … jessica kaya immobilien

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Web2) Post-translational modifications (PTMs) have the additional advantage of often being reversible — you don't need to make new proteins a cell can just fine tune their activity as … WebMelvin Sanicas’ Post Melvin Sanicas 15K Followers • Vaccinologist • TED Educator • Senior Director, Global Medical Affairs at Clover Biopharmaceuticals 1w Report this post ... Web23 Nov 2024 · About. • Data Scientist with 12+ years of experience in conceiving, designing and executing AI- and omics-intensive research projects (basic, translational, pre-clinical … lampada t8 diametro

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Nur77 variants solely comprising the amino-terminal domain …

WebNur77 is a nuclear orphan receptor that has been implicated in both cell survival and apoptosis. With the exception of T-cells, translocation of Nur77 to the cytoplasm … WebMulti-omic approaches offer an unprecedented overview of the development, plasticity, and resistance of cancer. However, the translation from anti-cancer compounds identified in vitroto clinically active drugs have a notoriously low success rate. lâmpada t8 ledWeb5 Nov 2024 · Nur77 is an orphan nuclear receptor implicated in the regulation of a wide range of biological processes, including the maintenance of systemic blood vessel homeostasis. Although Nur77 is known to be expressed in the lung, its role in regulating pulmonary vascular functions remains entirely unknown. lampada t8 e t5

"Web6 Jan 2024 · The phosphorylated Nur77 was detected by phos-tag SDS-PAGE assay and specific antibody against phospho-Nur77-Thr366. The effect of embryo-epithelium interaction was determined in the BeWo spheroid or mouse embryo adhesion assay, and delayed implantation mouse model. " - Post-translational control of nur77

Post-translational control of nur77

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Web1 Feb 2024 · Nur77 (Nr4a1, also known as Nerve-Growth Factor Inducible gene B, [NGFI-B] or TR3), together with Nurr1 (Nr4a2, TINUR), and Nor-1 (Nr4a3, MINOR) form the Nr4a … Web3 Sep 2014 · NIH-H460 cells were transfected with control or Nur77 siRNA for 48h, then treated with or without 5 μM apaensin for the indicated time. ... , suggesting its post …

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WebPost-translational control can be defined as the mechanisms by which protein structure can be altered after translation. Proteins are polymers of amino acids, and there are twenty different amino acids. Both the order and identity of these amino acids are important for the role that the protein plays in the cell. WebImmunogen: Full-length Mouse Nur77 fusion protein Application: Western blot (Routinely Tested), Flow cytometry (Tested During Development) Target Molecular Weight: 67-88 …

Web24 Jun 2024 · Consequently, MMP activity is tightly regulated through a combination of epigenetic, transcriptional, and post-transcriptional control of gene expression, proteolytic activation, post-translational modifications (PTMs), and extracellular inhibition. In addition, MMPs, their substrates and ECM binding partners are frequently modified by PTMs ... WebThe choroid is a vulnerable tissue site in the eye, impacted in several blinding diseases including age related macular degeneration (AMD), which is the leading cause of central vision loss in the aging population. Choroidal thinning and choriocapillary dropout are features of the early form of AMD, and endothelial dysfunction and vascular changes are …

Web21 Jan 2016 · Lysine-acetylation homeostasis is under the supervision of two families of enzymes, with antagonistic activities: the histone acetyl transferases and the histone deacetylases (HDACs). HDACs repertoire in mammals comprises 18 genes that can be grouped into five subfamilies on the basis of their sequence homology and phylogenetic … Web1 May 2006 · Proapoptotic nuclear receptor family member Nur77 translocates from the nucleus to the mitochondria, where it interacts with Bcl-2 to trigger apoptosis. Nur77 …

Web14 May 2024 · Nur77 post-translationally downregulates ID1 through mediating its association with and poly-ubiquitylation by Smurf2 Considering the Nur77 dependence of …

WebThe actions of lncRNAs in control of carcinogenesis and cancer progression via regulation of transporters and glycolytic enzymes are ... Guan et al found that nuclear receptor … jessica kayWeb5 Apr 2015 · Here, we examined the regulation of Nur77 expression, in response to apoptotic TCR signals, which consists of kinase C and calcium pathways. We show that the major … jessica kavana dornbuschWebNR4A1 (also called Nur77, TR3, or NGFIB) is an orphan nuclear receptor that belongs to the steroid/thyroid/retinoid receptor superfamily ( Hazel et al., 1988 ). NR4A1 contains DNA binding domain (DBD) and ligand binding domain (LBD) ( Lin et al., 2004 ), by which NR4A1 is activated and regulates gene expression ( Wu and Chen, 2024 ). lampada t8 led 240