WebJun 1, 2013 · The Hippo tumor suppressor pathway plays an important role in tissue homeostasis that ensures development of functional organs at proper size. The YAP … WebJun 8, 2024 · It was reported that O-GlcNAcylation enhances YAP activity (32, 39, 40).This finding establishes a correlation between abnormally high levels of O-GlcNAcylation and dysregulation of the Hippo pathway in cancer cells.Activated YAP induces transcription of NF2 and LATS2, which are involved in inactivating YAP/TAZ (41, 42).However, the …
Novel insights into the regulation of LATS2 kinase in …
WebIn our recent study , we have identified a ubiquitously expressed serine/threonine kinase, LATS2 (large tumor suppressor 2), and core signaling component in the Hippo pathway, … Webp53 protein is a well-known tumor suppressor factor that regulates cellular homeostasis. As it has several and key functions exerted, p53 is known as “the guardian of the genome” … subway\u0027s mission statement and vision
Hippo Signaling Pathway in Pancreatic β-Cells: Functions and ...
WebNational Center for Biotechnology Information WebMar 29, 2024 · The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa. Long noncoding … WebAngiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo ... AMOTL2 bound better to wild-type than kinase dead LATS2 , or LATS2 w ith both sites of painting contractors spruce grove